Motor Sequence Learning Performance in Parkinson's Disease Patients Depends on the Stage of Disease

Autor/inn/en	Stephan, Marianne A.; Meier, Beat; Zaugg, Sabine Weber; Kaelin-Lang, Alain
Titel	Motor Sequence Learning Performance in Parkinson's Disease Patients Depends on the Stage of Disease
Quelle	In: Brain and Cognition, 75 (2011) 2, S. 135-140 PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0278-2626
DOI	10.1016/j.bandc.2010.10.015
Schlagwörter	Forschungsbericht; Diseases; Incidental Learning; Rating Scales; Patients; Motor Reactions; Sequential Learning; Neurological Impairments; Severity (of Disability); Measures (Individuals); Scores; Correlation + Suchen Sie Ihr Suchwort? Disease; Krankheit; Inzidentelles Lernen; Rating-Skala; Patient; Didaktische Sequenzierung; Lernsequenz; Neurodegenerative Erkrankung; Schweregrad; Messdaten; Korrelation
Abstract	It is still unclear, whether patients with Parkinson's disease (PD) are impaired in the incidental learning of different motor sequences in short succession, although such a deficit might greatly impact their daily life. The aim of this study was thus to clarify the relation between disease parameters of PD and incidental motor learning of two different sequences in short succession. Results revealed that the PD patients were able to acquire two sequences in short succession but needed more time than healthy subjects. However, both the severity of axial manifestations, as assessed on a subsection of the Unified Parkinson's Disease Rating Scale III (UPDRS III) and the Hoehn and Yahr score, and the levodopa-equivalent dose (LED) were negatively correlated with the sequence learning performance. These findings indicate that, although PD patients are able to learn two sequences in short succession, they need more time and their overall sequence learning performance is strongly correlated with the stage of disease. (Contains 2 tables and 2 figures.) (As Provided).
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Begutachtung	Peer reviewed
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10