Childhood maltreatment is associated with changes in mitochondrial bioenergetics in maternal, but not in neonatal immune cells.

Autor/inn/en	Gumpp, Anja M.; Boeck, Christina; Behnke, Alexander; Bach, Alexandra M.; Ramo-Fernández, Laura; Welzb, Thilo; Gündel, Harald; Kolassa, Iris-Tatjana; Karabatsiakis, Alexander
Titel	Childhood maltreatment is associated with changes in mitochondrial bioenergetics in maternal, but not in neonatal immune cells. Gefälligkeitsübersetzung: Kindesmisshandlung wird mit Veränderungen der mitochondrialen Bioenergetik in mütterlichen, aber nicht in neonatalen Immunzellen in Verbindung gebracht.
Quelle	In: Proceedings of the National Academy of Sciences of the United States of America, 117 (2020) 40, S. 24778-24784 PDF als Volltext Link als defekt meldenVerfügbarkeit
Sprache	englisch
Dokumenttyp	online; Zeitschriftenaufsatz
ISSN	0027-8424; 1091-6490
DOI	10.1073/pnas.2005885117
Schlagwörter	Mutter-Kind-Beziehung; Transgenerationales Verhaltensmuster; Kindesmisshandlung; Kindesvernachlässigung; Genetik; Immunsystem; Mitochondrium
Abstract	Childhood maltreatment (CM) comprises experiences of abuse and neglect during childhood. CM causes psychological as well as biological alterations in affected individuals. In humans, it is hardly explored whether these CM consequences can be transmitted directly on a biological level to the next generation. Here, we investigated the associations between maternal CM and mitochondrial bioenergetics (mitochondrial respiration and intracellular mitochondrial density) in immune cells of mothers and compared them with those of their newborns. In n = 102 healthy mother-newborn dyads, maternal peripheral blood mononuclear cells and neonatal umbilical cord blood mononuclear cells were collected and cryopreserved shortly after parturition to measure mitochondrial respiration and intracellular mitochondrial density with high-resolution respirometry and spectrophotometric analyses, respectively. Maternal CM was assessed with the Childhood Trauma Questionnaire. Maternal and neonatal mitochondrial bioenergetics were quantitatively comparable and positively correlated. Female newborns showed higher mitochondrial respiration compared to male newborns. Maternal CM load was significantly and positively associated with mitochondrial respiration and density in mothers, but not with mitochondrial respiration in newborns. Although maternal and neonatal mitochondrial bioenergetics were positively correlated, maternal CM only had a small effect on mitochondrial density in newborns, which was not significant in this study after adjustment for multiple comparisons. The biological relevance of our finding and its consequences for child development need further investigation in future larger studies. This study reports data on mitochondrial bioenergetics of healthy mother-newborn dyads with varying degrees of CM. (ZPID).
Erfasst von	Leibniz-Institut für Psychologie, Trier
Update	2025/2