Exposure to childhood maltreatment and systemic inflammation across pregnancy: The moderating role of depressive symptomatology.

Autor/inn/en	Kleih, Theresa S.; Entringer, Sonja; Scholaske, Laura; Kathmann, Norbert; DePunder, Karin; Heim, Christine M.; Wadhwa, Pathik D.; Claudia, Buss
Titel	Exposure to childhood maltreatment and systemic inflammation across pregnancy: The moderating role of depressive symptomatology. Gefälligkeitsübersetzung: Misshandlungserfahrungen in der Kindheit und systemische Entzündungen während der Schwangerschaft: Die moderierende Rolle der depressiven Symptomatik.
Quelle	In: Brain, behavior and immunity, (2022) 101, S. 397-409 PDF als Volltext kostenfreie Datei Link als defekt meldenVerfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0889-1591; 1090-2139
DOI	10.1016/j.bbi.2022.02.004
Schlagwörter	Depression; Transgenerationales Verhaltensmuster; Kindesmisshandlung; Kindesvernachlässigung; Kindheit; Mutter; Immunsystem; Entzündung; Schwangerschaft; Problem
Abstract	BACKGROUND: Childhood maltreatment (CM) has long-term consequences for dysregulation of the immune system which is particularly pronounced when mental and physical health sequelae have manifested. Higher proinflammatory state has been shown in non-pregnant state in association with CM as wel l as with depression, one of the most frequent and pernicious psychiatric sequelae of CM. During pregnancy, however, this association is less clear. Given the important role of maternal inflammatory state during pregnancy for fetal, pregnancy, and birth outcomes, we sought to examine the association between CM and proinflammatory state during pregnancy considering the moderating role of maternal depressive symptoms characterized serially across pregnancy. METHODS: A prospective, longitudinal study of 180 healthy pregnant women was conducted with serial as-sessments in early (12.98 +/- 1.71 weeks gestation), mid (20.53 +/- 1.38 weeks gestation) and late (30.42 +/- 1.4 weeks gestation) pregnancy. Maternal history of CM was assessed with the Childhood Trauma Questionnaire (CTQ) and the total score was used as an indicator of CM experience. Maternal depressive symptoms were assessed at each pregnancy visit with the Center for Epidemiologic Studies Depression Scale (CES-D). Serum concentrations of tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 were obtained at each pregnancy visit and combined to a composite maternal proinflammator y score. Linear mixed effects models were employed to assess the association between CTQ score, CES-D score, and proinflammator y score during pregnancy, adjusting for potential confounders. RESULTS: Gestational age was associated with the proinflammator y score (B = 0.02; SE = 0.00; p ( .001), indicating an increase in inflammation across gestation. Neither CTQ score nor depressive symptoms were independently associated with the proinflammator y score (ps ) 0.28). However, the interaction between CTQ score and depressive symptoms was associated with the proinflammator y score (B = 0.03, SE = 0.01, p ( .05), indicating higher inflammation across pregnancy with increasing levels of depressive symptoms during preg-nancy in women with higher CTQ scores. Exploratory analyses suggested that this interaction was mainly driven by CTQ subscale scores assessing experiences of abuse rather than neglect. CONCLUSIONS: These findings suggest a moderating role of maternal depressive symptoms during pregnancy on the association of early life stress with inflammation and thus highlight the importance of the timely assessment of both CM exposure and depressive symptoms which might allow for the development of targeted and individualized interventions to impact inflammation during pregnancy and to ameliorate the detrimental long-term effects of CM. The current findings add to a better understanding of the prenatal biological pathways that may underlie intergenerational transmission of maternal CM. (ZPID).
Erfasst von	Leibniz-Institut für Psychologie, Trier
Update	2024/3