Abnormal fMRI Activation Pattern during Story Listening in Individuals with Down Syndrome

Autor/inn/en	Reynolds Losin, Elizabeth A.; Rivera, Susan M.; O'Hare, Elizabeth D.; Sowell, Elizabeth R.; Pinter, Joseph D.
Titel	Abnormal fMRI Activation Pattern during Story Listening in Individuals with Down Syndrome
Quelle	In: American Journal on Intellectual and Developmental Disabilities, 114 (2009) 5, S.369-380 (12 Seiten)Infoseite zur Zeitschrift PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1944-7515
DOI	10.1352/1944-7558-114.5.369
Schlagwörter	Down Syndrome; Young Adults; Receptive Language; Diagnostic Tests; Listening; Comparative Analysis; Brain Hemisphere Functions; Speech Communication; Speech Impairments; Language Impairments; Neurological Organization + Suchen Sie Ihr Suchwort? 'Downs Syndrome; Down''s Syndrome'; Down-Syndrom; Young adult; Junger Erwachsener; Rezeptive Kommunikationsfähigkeit; Diagnostic test; Diagnostischer Test; Hörvorgang; Zuhören; Speech impairment; Speech handicap; Speech handicaps; Language handicps; Language impairments; Sprachbehinderung; Speech disorder; Speech disorders; Speech disabilities; Speech disability; Speech impairments; Language handicaps
Abstract	Down syndrome is characterized by disproportionately severe impairments of speech and language, yet little is known about the neural underpinnings of these deficits. We compared fMRI activation patterns during passive story listening in 9 young adults with Down syndrome and 9 approximately age-matched, typically developing controls. The typically developing group exhibited greater activation than did the Down syndrome group in classical receptive language areas (superior and middle temporal gyri) for forward greater than backward speech; the Down syndrome group exhibited greater activation in cingulate gyrus, superior and inferior parietal lobules, and precuneus for both forward speech greater than rest and backward speech greater than rest. The Down syndrome group showed almost no difference in activation patterns between the language (forward speech) and nonlanguage (backward speech) conditions. (As Provided).
Anmerkungen	American Association on Intellectual and Developmental Disabilities. P.O. Box 1897, Lawrence, KS 66044-1897. Tel: 785-843-1235; Fax: 785-843-1274; e-mail: AJMR@allenpress.com; Web site: http://aaidd.allenpress.com
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10