The Search for Biomarkers of Alzheimer's Disease in Down Syndrome

Autor/in	Handen, Benjamin L.
Titel	The Search for Biomarkers of Alzheimer's Disease in Down Syndrome
Quelle	In: American Journal on Intellectual and Developmental Disabilities, 125 (2020) 2, S.97-99 (3 Seiten)Infoseite zur Zeitschrift PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1944-7515
Schlagwörter	Adults; Down Syndrome; Alzheimers Disease; At Risk Persons; Dementia; Genetic Disorders; Brain; Neurological Impairments + Suchen Sie Ihr Suchwort? 'Downs Syndrome; Down''s Syndrome'; Down-Syndrom; Risikogruppe; Demenz; Gehirn; Neurodegenerative Erkrankung
Abstract	Adults with Down syndrome are at high risk for Alzheimer's disease (AD), with most individuals developing clinical dementia by their late 60s. This increased risk for AD has been attributed, at least in part, to triplication and overexpression of the gene for amyloid precursor protein (APP) on chromosome 21, leading to elevated levels of amyloid [beta] peptides. This article offers a brief overview of our current knowledge of AD in the DS population. In addition, information on an NIA/NICHD-funded, multicenter longitudinal study of biomarkers of AD in adults with DS is provided. (As Provided).
Anmerkungen	American Association on Intellectual and Developmental Disabilities. P.O. Box 1897, Lawrence, KS 66044-1897. Tel: 785-843-1235; Fax: 785-843-1274; e-mail: AJMR@allenpress.com; Web site: http://www.aaiddjournals.org/
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01