Neuronal Substrates of Relapse to Cocaine-Seeking Behavior: Role of Prefrontal Cortex

Autor/inn/en	Rebec, George V.; Sun, WenLin
Titel	Neuronal Substrates of Relapse to Cocaine-Seeking Behavior: Role of Prefrontal Cortex
Quelle	In: Journal of the Experimental Analysis of Behavior, 84 (2005) 3, S.653-666 (14 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0022-5002
Schlagwörter	Addictive Behavior; Neurology; Cues; Cocaine; Brain Hemisphere Functions; Animals; Animal Behavior; Behavioral Science Research; Drug Use; Recidivism; Pharmacology; Models; Reinforcement + Suchen Sie Ihr Suchwort? Neurologie; Stichwort; Kokain; Animal; Tier; Tiere; Tierverhalten; Drug consumption; Substance abuse; Drogenkonsum; Rückfall; Arzneikunde; Analogiemodell; Positive Verstärkung
Abstract	The return to drug seeking, even after prolonged periods of abstinence, is a defining feature of cocaine addiction. The neural circuitry underlying relapse has been identified in neuropharmacological studies of experimental animals, typically rats, and supported in brain imaging studies of human addicts. Although the nucleus accumbens (NAcc), which has long been implicated in goal-directed behavior, plays a critical role in this circuit, the prefrontal cortex (PFC) appears to process the events that directly trigger relapse: exposure to acute stress, cues previously associated with the drug, and the drug itself. In this paper, we review animal models of relapse and what they have revealed about the mechanisms underlying the involvement of the NAcc and PFC in cocaine-seeking behavior. We also present electrophysiological data from PFC illustrating how the hedonic, motor, motivational, and reinforcing effects of cocaine can be analyzed at the neuronal level. Our preliminary findings suggest a role for PFC in processing information related to cocaine seeking but not the hedonic effects of the drug. Further use of this recording technology can help dissect the functions of PFC and other components of the neural circuitry underlying relapse. (Contains 4 figures.) (As Provided).
Anmerkungen	Society for the Experimental Analysis of Behavior. Available from: Indiana University Department of Psychology. Bloomington, IN 47405. Tel: 812-334-0395; Fax: 812-855-4691; e-mail: jeab@indiana.edu; Web site: http://seab.envmed.rochester.edu/jeab/index.html
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10