The Generation R Study: A Review of Design, Findings to Date, and a Study of the 5-HTTLPR by Environmental Interaction from Fetal Life Onward

Autor/inn/en	Tiemeier, Henning; Velders, Fleur P.; Szekely, Eszter; Roza, Sabine J.; Dieleman, Gwen; Jaddoe, Vincent W. V.; Uitterlinden, Andre G.; White, Tonya J. H.; Bakermans-Kranenburg, Marian J.; Hofman, Albert; Van IJzendoorn, Marinus H.; Hudziak, James J.; Verhulst, Frank C.
Titel	The Generation R Study: A Review of Design, Findings to Date, and a Study of the 5-HTTLPR by Environmental Interaction from Fetal Life Onward
Quelle	In: Journal of the American Academy of Child & Adolescent Psychiatry, 51 (2012) 11, S.1119-1135 (17 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0890-8567
DOI	10.1016/j.jaac.2012.08.021
Schlagwörter	Pregnancy; Emotional Development; Anxiety; Emotional Problems; Interaction; Environmental Influences; Psychiatry; Prenatal Influences; Perinatal Influences; Genetics; Mothers; Symptoms (Individual Disorders); Toddlers; Parent Influence; At Risk Persons; Child Development + Suchen Sie Ihr Suchwort? Schwangerschaft; Gefühlsbildung; Angst; Interaktion; Environmental influence; Umwelteinfluss; Psychiatrie; Pränataler Einfluss; Perinatalperiode; Humangenetik; Mother; Mutter; Psychiatrische Symptomatik; Infant; Infants; Toddler; Kleinkind; Risikogruppe; Kindesentwicklung
Abstract	Objective: First, we give an overview of child psychiatric research in the Generation R Study, a population-based cohort from fetal life forward. Second, we examine within Generation R whether the functional polymorphism (5-HTTLPR) in the promoter of the serotonin transporter gene interacts with prenatal maternal chronic difficulties, prenatal maternal anxiety or postnatal maternal anxiety to influence child emotional development. Method: A total of 2,136 northern European children were genotyped for 5-HTTLPR and rs25531. Mothers reported chronic difficulties and anxiety symptoms at 20 weeks' pregnancy and when the child was 3 years old. Child emotion recognition was observed at 3 years, and child emotional problems were assessed with the CBCL/1 1/2-5 at 5 years. Results: There were consistent main effects of maternal difficulties and anxiety on child emotional problems, but no main effect of 5-HTTLPR. Moreover, children with the s allele were at increased risk for emotional problems if their mothers reported prenatal anxiety symptoms (beta = 2.02, p less than 0.001) or postnatal anxiety symptoms (beta = 1.64, p less than 0.001). Also, in children of mothers with prenatal anxiety symptoms, the s allele was associated with less accurate emotion-matching (beta = -0.11, p = 0.004). Conclusions: This population-based study shows that vulnerability due to 5-HTTLPR is not specific for certain adverse exposures or severe events, but suggests that the small effects of gene-environment interaction on emotional development become manifest early in life. (Contains 10 tables and 3 figures.) (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10