Effects of Acute and Chronic Cocaine Administration on Titrating-Delay Matching-to-Sample Performance

Autor/inn/en	Kangas, Brian D.; Branch, Marc N.
Titel	Effects of Acute and Chronic Cocaine Administration on Titrating-Delay Matching-to-Sample Performance
Quelle	In: Journal of the Experimental Analysis of Behavior, 97 (2012) 2, S.151-161 (11 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0022-5002
Schlagwörter	Cocaine; Drug Abuse; Animals; Animal Behavior; Short Term Memory; Behavioral Science Research; Experimental Psychology + Suchen Sie Ihr Suchwort? Kokain; Animal; Tier; Tiere; Tierverhalten; Kurzzeitgedächtnis; Experimentelle Psychologie
Abstract	The effects of cocaine were examined under a titrating-delay matching-to-sample procedure. In this procedure, the delay between sample stimulus offset and comparison stimuli onset adjusts as a function of the subject's performance. Specifically, matches increase the delay and mismatches decrease the delay. Titrated delay values served as the primary dependent measure. After establishing stable performance in pigeons, several behaviorally-effective doses of cocaine were administered acutely. Dose-related within-session decreases in titrated delay values were observed. Following acute determinations, the dose of cocaine that produced the most rapid decline without eliminating performance was administered prior to each daily session. Chronic administration resulted in performance trending toward control levels. A redetermination of the dose-response function following chronic exposure revealed reduced potency (i.e., tolerance) under cocaine on titrated delay matching-to-sample performance. Supplemental analyses suggest that cocaine may serve as a disruptor of the stimulus conditions in which the performance was established. (Contains 5 figures.) (As Provided).
Anmerkungen	Society for the Experimental Analysis of Behavior. Available from: Indiana University Department of Psychology. Bloomington, IN 47405-1301. Tel: 812-334-0395; FAX: 812-855-4691; e-mail: jeab@indiana.edu; Web site: http://seab.envmed.rochester.edu/jeab/index.html
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10