Literaturnachweis - Detailanzeige
| Autor/inn/en | Boyle, Jeff; Otty, Sandra; Sarojini, Vijayalekshmi |
|---|---|
| Titel | A Safer and Convenient Synthesis of Sulfathiazole for Undergraduate Organic and Medicinal Chemistry Classes |
| Quelle | In: Journal of Chemical Education, 89 (2012) 1, S.141-143 (3 Seiten)Infoseite zur Zeitschrift
PDF als Volltext |
| Sprache | englisch |
| Dokumenttyp | gedruckt; online; Zeitschriftenaufsatz |
| ISSN | 0021-9584 |
| DOI | 10.1021/ed101120b |
| Schlagwörter | College Science; Undergraduate Study; Science Instruction; Chemistry; Science Laboratories; Pharmacology; Drug Therapy; Organic Chemistry; Biochemistry; Spectroscopy; Safety |
| Abstract | A safer method for the synthesis of the sulfonamide drug sulfathiazole, for undergraduate classes, is described. This method improves upon procedures currently followed in several undergraduate teaching laboratories for the synthesis of sulfathiazole. Key features of this procedure include the total exclusion of pyridine, which has potential health hazards, from the first step of the synthesis and a simplified procedure for converting the intermediate p-acetamidobenzenesulfonamide to the final product by acid hydrolysis. Characterization of the synthetic sulfathiazole obtained by the modified route was achieved using MS, NMR, and antibacterial activity testing of the synthetic product against "Escherichia coli" DH5[alpha]. (Contains 2 tables and 2 schemes.) (As Provided). |
| Anmerkungen | Division of Chemical Education, Inc and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail: eic@jce.acs.org; Web site: http://pubs.acs.org/jchemeduc |
| Erfasst von | ERIC (Education Resources Information Center), Washington, DC |
| Update | 2017/4/10 |
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