The Neural Basis of Reversible Sentence Comprehension: Evidence from Voxel-Based Lesion Symptom Mapping in Aphasia

Autor/inn/en	Thothathiri, Malathi; Kimberg, Daniel Y.; Schwartz, Myrna F.
Titel	The Neural Basis of Reversible Sentence Comprehension: Evidence from Voxel-Based Lesion Symptom Mapping in Aphasia
Quelle	In: Journal of Cognitive Neuroscience, 24 (2012) 1, S.212-222 (11 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0898-929X
DOI	10.1162/jocn_a_00118
Schlagwörter	Evidence; Sentences; Aphasia; Patients; Short Term Memory; Cognitive Processes; Neurological Impairments; Science Education; Correlation; Syntax; Brain + Suchen Sie Ihr Suchwort? Evidenz; Sentence analysis; Satzanalyse; Expressive Aphasie; Aphasie; Patient; Kurzzeitgedächtnis; Cognitive process; Kognitiver Prozess; Neurodegenerative Erkrankung; Naturwissenschaftliche Bildung; Korrelation; Gehirn
Abstract	We explored the neural basis of reversible sentence comprehension in a large group of aphasic patients (n = 79). Voxel-based lesion symptom mapping revealed a significant association between damage in temporo-parietal cortex and impaired sentence comprehension. This association remained after we controlled for phonological working memory. We hypothesize that this region plays an important role in the thematic or what-where processing of sentences. In contrast, we detected weak or no association between reversible sentence comprehension and the ventrolateral pFC, which includes Broca's area, even for syntactically complex sentences. This casts doubt on theories that presuppose a critical role for this region in syntactic computations. (As Provided).
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Update	2017/4/10