Activation of the Hippocampal Complex during Tactile Maze Solving in Congenitally Blind Subjects

Autor/inn/en	Gagnon, Lea; Schneider, Fabien C.; Siebner, Hartwig R.; Paulson, Olaf B.; Kupers, Ron; Ptito, Maurice
Titel	Activation of the Hippocampal Complex during Tactile Maze Solving in Congenitally Blind Subjects
Quelle	In: Neuropsychologia, 50 (2012) 7, S.1663-1671 (9 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0028-3932
DOI	10.1016/j.neuropsychologia.2012.03.022
Schlagwörter	Cues; Blindness; Vision; Cognitive Mapping; Brain Hemisphere Functions; Metabolism; Performance; Spatial Ability; Navigation; Responses; Diagnostic Tests; Task Analysis; Control Groups + Suchen Sie Ihr Suchwort? Stichwort; Blindheit; Stoffwechsel; Achievement; Leistung; Räumliches Vorstellungsvermögen; Diagnostic test; Diagnostischer Test; Aufgabenanalyse
Abstract	Despite their lack of vision, congenitally blind subjects are able to build and manipulate cognitive maps for spatial navigation. It is assumed that they thereby rely more heavily on echolocation, proprioceptive signals and environmental cues such as ambient temperature and audition to compensate for their lack of vision. Little is known, however, about the neural mechanisms underlying spatial navigation in blind individuals in settings where these cues are absent. We therefore measured behavioural performance and blood oxygenation-level dependant (BOLD) responses using functional magnetic resonance imaging (fMRI) in congenitally blind and blindfolded sighted participants while they navigated through a tactile multiple T-maze. Both groups learned the maze task at a similar pace. In blind participants, tactile maze navigation was associated with increased BOLD responses in the right hippocampus and parahippocampus, occipital cortex and fusiform gyrus. Blindfolded sighted controls did not show increased BOLD responses in these areas; instead they activated the caudate nucleus and thalamus. Both groups activated the precuneus during tactile maze navigation. We conclude that cross-modal plastic processes allow for the recruitment of the hippocampal complex and visual cortex in congenital blindness. (Contains 3 tables and 6 figures.) (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10