Basal Ganglia Structures Differentially Contribute to Verbal Fluency: Evidence from Human Immunodeficiency Virus (HIV)-Infected Adults

Autor/inn/en	Thames, April D.; Foley, Jessica M.; Wright, Matthew J.; Panos, Stella E.; Ettenhofer, Mark; Ramezani, Amir; Streiff, Vanessa; El-Saden, Suzie; Goodwin, Scott; Bookheimer, Susan Y.; Hinkin, Charles H.
Titel	Basal Ganglia Structures Differentially Contribute to Verbal Fluency: Evidence from Human Immunodeficiency Virus (HIV)-Infected Adults
Quelle	In: Neuropsychologia, 50 (2012) 3, S.390-395 (6 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0028-3932
DOI	10.1016/j.neuropsychologia.2011.12.010
Schlagwörter	Evidence; Acquired Immunodeficiency Syndrome (AIDS); Phonemics; Semantics; Integrity; Language Fluency; Semiotics; Adults; Measures (Individuals); Verbal Communication; Neurological Organization; Brain + Suchen Sie Ihr Suchwort? Evidenz; Fonemsystem; Semantik; Integrität; Language skill; Language skills; Sprachkompetenz; Semiotik; Messdaten; Gehirn
Abstract	Background: The basal ganglia (BG) are involved in executive language functions (i.e., verbal fluency) through their connections with cortical structures. The caudate and putamen receive separate inputs from prefrontal and premotor cortices, and may differentially contribute to verbal fluency performance. We examined BG integrity in relation to lexico-semantic verbal fluency performance among older HIV infected adults. Method: 20 older (50+ years) HIV+ adults underwent MRI and were administered measures of semantic and phonemic fluency. BG (caudate, putamen) regions of interest were extracted. Results: Performance on phonemic "word generation" significantly predicted caudate volume, whereas performance on phonemic "switching" predicted putamen volume. Conclusions: These findings suggest a double dissociation of BG involvement in verbal fluency tasks with the caudate subserving word generation and the putamen associated with switching. As such, verbal fluency tasks appear to be selective to BG function. (Contains 3 tables and 1 figure.) (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10