Difficulty Processing Temporary Syntactic Ambiguities in Lewy Body Spectrum Disorder

Autor/inn/en	Grossman, Murray; Gross, Rachel G.; Moore, Peachie; Dreyfuss, Michael; McMillan, Corey T.; Cook, Philip A.; Ash, Sherry; Siderowf, Andrew
Titel	Difficulty Processing Temporary Syntactic Ambiguities in Lewy Body Spectrum Disorder
Quelle	In: Brain and Language, 120 (2012) 1, S.52-60 (9 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0093-934X
DOI	10.1016/j.bandl.2011.08.007
Schlagwörter	Sentence Structure; Form Classes (Languages); Dementia; Diseases; Patients; Short Term Memory; Grammar; Neurological Impairments; Cognitive Ability; Correlation; Regression (Statistics); Ambiguity (Semantics); Verbs; Role + Suchen Sie Ihr Suchwort? Satzbau; Satzstruktur; Analytischer Sprachbau; Demenz; Disease; Krankheit; Patient; Kurzzeitgedächtnis; Grammatik; Neurodegenerative Erkrankung; Denkfähigkeit; Korrelation; Regression; Regressionsanalyse; Rollen
Abstract	While grammatical aspects of language are preserved, executive deficits are prominent in Lewy body spectrum disorder (LBSD), including Parkinson's disease (PD), Parkinson's dementia (PDD) and dementia with Lewy bodies (DLB). We examined executive control during sentence processing in LBSD by assessing temporary structural ambiguities. Using an on-line word detection procedure, patients heard sentences with a syntactic structure that has high-compatibility or low-compatibility with the main verb's statistically preferred syntactic structure, and half of the sentences were lengthened strategically between the onset of the ambiguity and its resolution. We found selectively slowed processing of lengthened ambiguous sentences in the PDD/DLB subgroup. This correlated with impairments on measures of executive control. Regression analyses related the working memory deficit during ambiguous sentence processing to significant cortical thinning in frontal and parietal regions. These findings emphasize the role of prefrontal disease in the executive limitations that interfere with processing ambiguous sentences in LBSD. (Contains 3 tables and 2 figures.) (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10