Cognition and Lobar Morphology in Full Mutation Boys with Fragile X Syndrome

Autor/inn/en	Meguid, Nagwa A.; Fahim, Cherine; Sami, Rasha; Nashaat, Neveen H.; Yoon, Uicheul; Anwar, Mona; El-Dessouky, Hosam M.; Shahine, Elham A.; Ibrahim, Ahmed Samir; Mancini-Marie, Adham; Evans, Alan C.
Titel	Cognition and Lobar Morphology in Full Mutation Boys with Fragile X Syndrome
Quelle	In: Brain and Cognition, 78 (2012) 1, S.74-84 (11 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0278-2626
DOI	10.1016/j.bandc.2011.09.005
Schlagwörter	Mental Retardation; Regression (Statistics); Brain Hemisphere Functions; Males; Genetic Disorders; Autism; Comparative Analysis; Behavior Problems; Diagnostic Tests; Children; Physiology; Neurology + Suchen Sie Ihr Suchwort? Geistige Behinderung; Regression; Regressionsanalyse; Male; Männliches Geschlecht; Autismus; Diagnostic test; Diagnostischer Test; Child; Kind; Kinder; Physiologie; Neurologie
Abstract	The aims of the present study are twofold: (1) to examine cortical morphology (CM) associated with alterations in cognition in fragile X syndrome (FXS); (2) to characterize the CM profile of FXS versus FXS with an autism diagnosis (FXS+Aut) as a preliminary attempt to further elucidate the behavioral distinctions between the two sub-groups. We used anatomical magnetic resonance imaging surface-based morphometry in 21 male children (FXS N = 11 and age [2.27-13.3] matched controls [C] N = 10). We found (1) increased whole hemispheric and lobar cortical volume, cortical thickness and cortical complexity bilaterally, yet insignificant changes in hemispheric surface area and gyrification index in FXS compared to C; (2) linear regression analyses revealed significant "negative" correlations between CM and cognition; (3) significant CM differences between FXS and FXS + Aut associated with their distinctive behavioral phenotypes. These findings are critical in understanding the neuropathophysiology of one of the most common intellectual deficiency syndromes associated with altered cognition as they provide human in vivo information about genetic control of CM and cognition. (Contains 3 tables and 2 figures.) (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10