Genome-Wide Association Study of the Child Behavior Checklist Dysregulation Profile

Autor/inn/en	Mick, Eric; McGough, James; Loo, Sandra; Doyle, Alysa E.; Wozniak, Janet; Wilens, Timothy E.; Smalley, Susan; McCracken, James; Biederman, Joseph; Faraone, Stephen V.
Titel	Genome-Wide Association Study of the Child Behavior Checklist Dysregulation Profile
Quelle	In: Journal of the American Academy of Child & Adolescent Psychiatry, 50 (2011) 8, S.807-817 (11 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0890-8567
DOI	10.1016/j.jaac.2011.05.001
Schlagwörter	Attention Deficit Hyperactivity Disorder; Check Lists; Aggression; Psychopathology; Child Behavior; Profiles; Genetics; Brain; Behavior Disorders; Children; Family Characteristics; Correlation; Anxiety Disorders; Emotional Disturbances; Depression (Psychology); Genetic Disorders; California; Massachusetts; Child Behavior Checklist + Suchen Sie Ihr Suchwort? Checkliste; Psychopathologie; Charakterisierung; Profilanalyse; Humangenetik; Gehirn; Child; Kind; Kinder; Korrelation; Gefühlsstörung; Kalifornien; Master-Studiengang
Abstract	Objective: A potentially useful tool for understanding the distribution and determinants of emotional dysregulation in children is a Child Behavior Checklist profile, comprising the Attention Problems, Anxious/Depressed, and Aggressive Behavior clinical subscales (CBCL-DP). The CBCL-DP indexes a heritable trait that increases susceptibility for later psychopathology, including severe mood problems and aggressive behavior. We have conducted a genome-wide association study of the CBCL-DP in children with attention-deficit/hyperactivity disorder (ADHD). Method: Families were ascertained at Massachusetts General Hospital and University of California, Los Angeles. Genotyping was conducted with the Illumina Human1M or Human1M-Duo BeadChip platforms. Genome-wide association analyses were conducted with the MQFAM multivariate extension of PLINK. Results: CBCL data were available for 341 ADHD offspring from 339 ADHD affected trio families from the UCLA (N = 128) and the MGH (N = 213) sites. We found no genome-wide statistically significant associations but identified several plausible candidate genes among findings at p less than 5E-05: "TMEM132D," "LRRC7," "SEMA3A," "ALK," and "STIP1" Conclusions: We found suggestive evidence for developmentally expressed genes operant in hippocampal dependent memory and learning with the CBCL-DP. (Contains 2 figures and 3 tables.) (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10