Brief Report: "Allergic Symptoms" in Children with Autism Spectrum Disorders. More than Meets the Eye?

Autor/inn/en	Angelidou, Asimenia; Alysandratos, Konstantinos-Dionysios; Asadi, Shahrzad; Zhang, Bodi; Francis, Konstantinos; Vasiadi, Magdalini; Kalogeromitros, Dimitrios; Theoharides, Theoharis C.
Titel	Brief Report: "Allergic Symptoms" in Children with Autism Spectrum Disorders. More than Meets the Eye?
Quelle	In: Journal of Autism and Developmental Disorders, 41 (2011) 11, S.1579-1585 (7 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0162-3257
DOI	10.1007/s10803-010-1171-z
Schlagwörter	Autism; Pathology; Brain; Pervasive Developmental Disorders; Children; Child Health; Symptoms (Individual Disorders); Diseases; Incidence + Suchen Sie Ihr Suchwort? Autismus; Pathologie; Gehirn; Child; Kind; Kinder; Psychiatrische Symptomatik; Disease; Krankheit; Vorkommen
Abstract	Many children with Autism Spectrum Disorders (ASD) have either family and/or personal history of "allergic symptomatology", often in the absence of positive skin or RAST tests. These symptoms may suggest mast cell activation by non-allergic triggers. Moreover, children with mastocytosis or mast cell activation syndrome (MCAS), a spectrum of rare diseases characterized by increased number of activated mast cells in many organs, appear to have ASD at a rate tenfold higher (1/10 children) than that of the general population (1/100 children). Mast cell activation by allergic, infectious, environmental and stress-related triggers, especially perinatally, would release pro-inflammatory and neurotoxic molecules. We speculate these could disrupt the gut-blood-brain barriers, thus contributing to brain inflammation and ASD pathogenesis. Increased mast cell responsiveness may define at least a subgroup of ASD subjects, who could benefit from inhibition of mast cell activation. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10