Context Fear Learning Specifically Activates Distinct Populations of Neurons in Amygdala and Hypothalamus

Autor/inn/en	Trogrlic, Lidia; Wilson, Yvette M.; Newman, Andrew G.; Murphy, Mark
Titel	Context Fear Learning Specifically Activates Distinct Populations of Neurons in Amygdala and Hypothalamus
Quelle	In: Learning & Memory, 18 (2011) 10, S.678-687 (10 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.2314311
Schlagwörter	Conditioning; Recall (Psychology); Fear; Context Effect; Brain Hemisphere Functions; Learning Processes; Memory; Genetics + Suchen Sie Ihr Suchwort? Abberufung; Furcht; Learning process; Lernprozess; Gedächtnis; Humangenetik
Abstract	The identity and distribution of neurons that are involved in any learning or memory event is not known. In previous studies, we identified a discrete population of neurons in the lateral amygdala that show learning-specific activation of a c-"fos"-regulated transgene following context fear conditioning. Here, we have extended these studies to look throughout the amygdala for learning-specific activation. We identified two further neuronal populations, in the amygdalo-striatal transition area and medial amygdala, that show learning-specific activation. We also identified a population of hypothalamic neurons that show strong learning-specific activation. In addition, we asked whether these neurons are activated following recall of fear-conditioning memory. None of the populations of neurons we identified showed significant memory-recall-related activation. These findings suggest that a series of discrete populations of neurons are involved in fear learning in amygdala and hypothalamus. The lack of reactivation during memory recall suggests that these neurons either do not undergo substantial change following recall, or that c-"fos" is not involved in any such activation and change. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10