Retention and Extinction of Delay Eyeblink Conditioning Are Modulated by Central Cannabinoids

Autor/inn/en	Steinmetz, Adam B.; Freeman, John H.
Titel	Retention and Extinction of Delay Eyeblink Conditioning Are Modulated by Central Cannabinoids
Quelle	In: Learning & Memory, 18 (2011) 10, S.634-638 (5 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.2254111
Schlagwörter	Conditioning; Eye Movements; Animals; Marijuana; Drug Therapy; Training; Retention (Psychology) + Suchen Sie Ihr Suchwort? Augenbewegung; Animal; Tier; Tiere; Ausbildung; Merkfähigkeit
Abstract	Rats administered the cannabinoid agonist WIN55,212-2 or the antagonist SR141716A exhibit marked deficits during acquisition of delay eyeblink conditioning, as noted by Steinmetz and Freeman in an earlier study. However, the effects of these drugs on retention and extinction of eyeblink conditioning have not been assessed. The present study examined the effects of WIN55,212-2 and SR141716A on retention and extinction of delay eyeblink conditioning in rats. Rats were given acquisition training for five daily sessions followed by one session of retention training with subcutaneous administration of 3 mg/kg of WIN55,212-2 or 5 mg/kg of SR141716A and an additional session with the vehicle. Two sessions of extinction training were then given with WIN55,212-2, SR141716A, or vehicle. Retention and extinction were impaired by WIN55,212-2, whereas SR141716A produced no deficits. The extinction deficit in rats given WIN55,212-2 was observed only during the first session, suggesting a specific impairment in short-term plasticity mechanisms. The current results and previous findings indicate that the cannabinoid system modulates cerebellar contributions to acquisition, retention, and extinction of eyeblink conditioning. (Contains 4 figures.) (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10