Literaturnachweis - Detailanzeige
| Autor/inn/en | Martel, Michelle M.; Nikolas, Molly; Jernigan, Katherine; Friderici, Karen; Waldman, Irwin; Nigg, Joel T. |
|---|---|
| Titel | The Dopamine Receptor D4 Gene ("DRD4") Moderates Family Environmental Effects on ADHD |
| Quelle | In: Journal of Abnormal Child Psychology, 39 (2011) 1, S.1-10 (10 Seiten)
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| Sprache | englisch |
| Dokumenttyp | gedruckt; online; Zeitschriftenaufsatz |
| ISSN | 0091-0627 |
| DOI | 10.1007/s10802-010-9439-5 |
| Schlagwörter | Conflict; Attention Deficit Hyperactivity Disorder; Attention Deficit Disorders; Child Rearing; Risk; Parent Child Relationship; Genetics; Correlation; Marital Satisfaction; Behavior Disorders; Family Environment |
| Abstract | Attention-Deficit/Hyperactivity Disorder (ADHD) is a prime candidate for exploration of gene-by-environment interaction (i.e., G x E), particularly in relation to dopamine system genes, due to strong evidence that dopamine systems are dysregulated in the disorder. Using a G x E design, we examined whether the "DRD4" promoter 120-bp tandem repeat polymorphism, previously associated with ADHD, moderated the effects of inconsistent parenting and marital conflict on ADHD or Oppositional-Defiant Disorder (ODD). Participants were 548 children with ADHD and non-ADHD comparison children and their parents. Homozygosity for the "DRD4" promoter 120-bp tandem repeat insertion allele increased vulnerability for ADHD and ODD only in the presence of inconsistent parenting and appeared to increase susceptibility to the influence of increased child self-blame for marital conflict on ADHD inattention. "DRD4" genotypes may interact with these proximal family environmental risk factors by increasing the individual's responsivity to environmental contingencies. (As Provided). |
| Anmerkungen | Springer. 233 Spring Street, New York, NY 10013. Tel: 800-777-4643; Tel: 212-460-1500; Fax: 212-348-4505; e-mail: service-ny@springer.com; Web site: http://www.springerlink.com |
| Erfasst von | ERIC (Education Resources Information Center), Washington, DC |
| Update | 2017/4/10 |
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