The Effect of D-Cycloserine on Immediate vs. Delayed Extinction of Learned Fear

Autor/inn/en	Langton, Julia M.; Richardson, Rick
Titel	The Effect of D-Cycloserine on Immediate vs. Delayed Extinction of Learned Fear
Quelle	In: Learning & Memory, 17 (2010) 11, S.547-551 (5 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.1927310
Schlagwörter	Conditioning; Fear; Effect Size; Learning Processes; Comparative Analysis; Drug Use; Animals + Suchen Sie Ihr Suchwort? Furcht; Learning process; Lernprozess; Drug consumption; Substance abuse; Drogenkonsum; Animal; Tier; Tiere
Abstract	We compared the effect of D-cycloserine (DCS) on immediate (10 min after conditioning) and delayed (24 h after conditioning) extinction of learned fear in rats. DCS facilitated both immediate and delayed extinction when the drug was administered after extinction training. However, DCS did not facilitate immediate extinction when administered prior to extinction training (i.e., when the interval between drug administration and shock was reduced). In addition, administering five, but not two, shocks prior to extinction training disrupted the facilitating effects of DCS on delayed extinction. These results suggest that aversive experiences prior to DCS administration can prevent it from facilitating extinction. (As Provided).
Anmerkungen	Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://www.learnmem.org/
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10