Universal Newborn Screening and Adverse Medical Outcomes: A Historical Note

Autor/inn/en	Brosco, Jeffrey P.; Seider, Michael I.; Dunn, Angela C.
Titel	Universal Newborn Screening and Adverse Medical Outcomes: A Historical Note
Quelle	In: Mental Retardation and Developmental Disabilities Research Reviews, 12 (2006) 4, S.262-269 (8 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1080-4013
DOI	10.1002/mrdd.20123
Schlagwörter	Medical Services; Test Results; Screening Tests; Diseases; Neonates; Public Policy; Metabolism; Genetic Disorders; Program Effectiveness; Literature Reviews; At Risk Persons; Death; Trend Analysis; Children + Suchen Sie Ihr Suchwort? Arzt; Screening-Verfahren; Disease; Krankheit; Neugeborenes Kind; Öffentliche Ordnung; Stoffwechsel; Risikogruppe; Sterbefall; Tod; Todesfall; Trendanalyse; Child; Kind; Kinder
Abstract	Universal newborn screening programs for metabolic disorders are typically described as a triumph of medicine and public policy in the US over the last 50 years. Advances in science and technology, including the Human Genome Project, offer the opportunity to expand universal newborn screening programs to include many additional metabolic and genetic conditions. Although the benefits of such screening programs appear to outweigh their costs, some critics have claimed that historical examples of inadvertent harm ensuing from false-positive screening results and subsequent inappropriate medical treatment should make us wary of expanding universal newborn screening. In this essay, we report the results of a review of the published literature to assess whether the extension of screening from at risk populations to all newborns led to substantial morbidity and mortality from misguided medical treatment. We provide a historical overview of universal newborn screening programs in the United States, and then focus on six early NBS programs: congenital hypothyroidism, phenylketonuria, congenital adrenal hyperplasia, galactosemia, sickle cell disease, and maple syrup urine disease. Our comprehensive search of published sources did not reveal a widespread problem of harm ensuing from medical treatment of children with false positive screening test results. (Contains 1 table.) (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10