"Asparagus Racemosus" Enhances Memory and Protects against Amnesia in Rodent Models

Autor/inn/en	Ojha, Rakesh; Sahu, Alakh N.; Muruganandam, A. V.; Singh, Gireesh Kumar; Krishnamurthy, Sairam
Titel	"Asparagus Racemosus" Enhances Memory and Protects against Amnesia in Rodent Models
Quelle	In: Brain and Cognition, 74 (2010) 1, S.1-9 (9 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0278-2626
DOI	10.1016/j.bandc.2010.05.009
Schlagwörter	Neurological Impairments; Memory; Brain Hemisphere Functions; Animals; Task Analysis; Learning Processes; Drug Use; Models + Suchen Sie Ihr Suchwort? Neurodegenerative Erkrankung; Gedächtnis; Animal; Tier; Tiere; Aufgabenanalyse; Learning process; Lernprozess; Drug consumption; Substance abuse; Drogenkonsum; Analogiemodell
Abstract	"Asparagus Racemosus" (AR) is an Ayurvedic rasayana possessing multiple neuropharmacological activities. The adpatogenic and antidepressant activity of AR is well documented. The present study was undertaken to assess nootropic and anti-amnesic activities of MAR in rats. The Morris water maze (MWM) and elevated plus maze (EPM) models were employed to evaluate learning and memory activity. Subsequently, the anti-amnestic activity was evaluated in scopolamine and sodium nitrite (NaNO[subscript 2])-induced amnestic models in rats. Rats pre-treated with MAR (50, 100 and 200mg/kg, p.o) for 7 days showed significant decrease in escape latency in the MWM test indicating nootropic activity. MAR also significantly reversed scopolamine and sodium nitrite-induced increase in transfer latency on EPM indicating anti-amnesic activity. Further, MAR dose-dependently inhibited acetylcholinesterase enzyme in specific brain regions (prefrontal cortex, hippocampus and hypothalamus). Thus, MAR showed nootropic and anti-amnesic activities in the models tested and these effects may probably be mediated through augmentation of cholinergic system due to its anti-cholinesterase activity. (Contains 4 tables and 5 figures.) (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10