Suppressing the Morning Rise in Cortisol Impairs Free Recall

Autor/inn/en	Rimmele, Ulrike; Meier, Flurina; Lange, Tanja; Born, Jan
Titel	Suppressing the Morning Rise in Cortisol Impairs Free Recall
Quelle	In: Learning & Memory, 17 (2010) 4, S.186-190 (5 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.1728510
Schlagwörter	Recall (Psychology); Recognition (Psychology); Biochemistry; Males + Suchen Sie Ihr Suchwort? Abberufung; Recognition; Wiedererkennen; Biochemie; Male; Männliches Geschlecht
Abstract	Elevated glucocorticoid levels impair memory retrieval. We investigated whether retrieval under naturally elevated glucocorticoid levels, i.e., during the morning rise in cortisol can be improved by suppressing cortisol. In a crossover study 16 men retrieved emotional and neutral texts and pictures (learned 3 d earlier) 30 min after morning awakening, following administration of the cortisol synthesis inhibitor metyrapone or placebo. Unexpectedly, the metyrapone-induced cortisol suppression significantly impaired free recall of both materials. Recognition remained unaffected. Thus, not only high, but also very low glucocorticoid levels impair retrieval, with the latter effect possibly reflecting insufficient occupation of hippocampal/amygdalar mineralocorticoid receptors (MRs). (As Provided).
Anmerkungen	Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://www.learnmem.org/
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10