A Choice Procedure to Assess the Aversive Effects of Drugs in Rodents

Autor/inn/en	Podlesnik, Christopher A.; Jimenez-Gomez, Corina; Woods, James H.
Titel	A Choice Procedure to Assess the Aversive Effects of Drugs in Rodents
Quelle	In: Journal of the Experimental Analysis of Behavior, 93 (2010) 2, S.203-223 (21 Seiten) PDF als Volltext (1); PDF als Volltext kostenfreie Datei (2) Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0022-5002
Schlagwörter	Positive Reinforcement; Drug Use; Animals; Punishment; Behavior Modification; Experimental Psychology; Operant Conditioning; Food + Suchen Sie Ihr Suchwort? Drug consumption; Substance abuse; Drogenkonsum; Animal; Tier; Tiere; Bestrafung; Behaviour modification; Verhaltensänderung; Experimentelle Psychologie; Operante Konditionierung; Lebensmittel
Abstract	The goal of this series of experiments was to develop an operant choice procedure to examine rapidly the punishing effects of intravenous drugs in rats. First, the cardiovascular effects of experimenter-administered intravenous histamine, a known aversive drug, were assessed to determine a biologically active dose range. Next, rats responded on each of two levers with concurrently available fixed-ratio 1 schedules of food reinforcement. Intravenous histamine was delivered along with food when responses were made on one of the options, and the lever on which both food and histamine were contingent was switched on a regular basis. A dose of 1.0 mg/kg/inj of histamine was effective in moving responding to the alternate lever, whereas saline, 0.1, or 0.3 mg/kg/inj of histamine were not. Histamine injections produced reliable selection of the alternate lever when they were presented on the same lever for three consecutive sessions, but not when they were switched between levers on each session. In addition, histamine produced greater selection of the alternate lever when it was presented with shorter intertrial interval durations. These findings indicate that, with appropriate parameters, the aversive effects of histamine and perhaps other drugs can be rapidly established using a concurrent choice procedure. (Contains 9 figures.) (As Provided).
Anmerkungen	Society for the Experimental Analysis of Behavior. Available from: Indiana University Department of Psychology. Bloomington, IN 47405-1301. Tel: 812-334-0395; FAX: 812-855-4691; e-mail: jeab@indiana.edu; Web site: http://seab.envmed.rochester.edu/jeab/index.html
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10