Research Review: Cholinergic Mechanisms, Early Brain Development, and Risk for Schizophrenia

Autor/inn/en	Ross, Randal G.; Stevens, Karen E.; Proctor, William R.; Leonard, Sherry; Kisley, Michael A.; Hunter, Sharon K.; Freedman, Robert; Adams, Catherine E.
Titel	Research Review: Cholinergic Mechanisms, Early Brain Development, and Risk for Schizophrenia
Quelle	In: Journal of Child Psychology and Psychiatry, 51 (2010) 5, S.535-549 (15 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0021-9630
DOI	10.1111/j.1469-7610.2009.02187.x
Schlagwörter	Schizophrenia; Mental Disorders; Attention Deficit Disorders; Brain; Therapy; Symptoms (Individual Disorders); Correlation; Prevention; Developmental Stages; Genetics; Biochemistry; Nutrition; Perinatal Influences + Suchen Sie Ihr Suchwort? Schizophrenie; Mental illness; Geisteskrankheit; Attention deficit hyperactivity disorder; ADHS; Aufmerksamkeits-Defizit-Hyperaktivitäts-Störung; Aufmerksamkeitsstörung; Gehirn; Therapie; Psychiatrische Symptomatik; Korrelation; Prävention; Vorbeugung; Humangenetik; Biochemie; Ernährung; Perinatalperiode
Abstract	The onset of diagnostic symptomology for neuropsychiatric diseases is often the end result of a decades-long process of aberrant brain development. Identification of novel treatment strategies aimed at normalizing early brain development and preventing mental illness should be a major therapeutic goal. However, there are few models for how this goal might be achieved. This review uses the development of a psychophysiological correlate of attentional deficits in schizophrenia to propose a developmental model with translational primary prevention implications. Review of genetic and neurobiological studies suggests that an early interaction between alpha7 nicotinic receptor density and choline availability may contribute to the development of schizophrenia-associated attentional deficits. Therapeutic implications, including perinatal dietary choline supplementation, are discussed. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10