Late-Treated Phenylketonuria and Partial Reversibility of Intellectual Impairment

Autor/in	Grosse, Scott D.
Titel	Late-Treated Phenylketonuria and Partial Reversibility of Intellectual Impairment
Quelle	In: Child Development, 81 (2010) 1, S.200-211 (12 Seiten)Infoseite zur Zeitschrift PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0009-3920
DOI	10.1111/j.1467-8624.2009.01389.x
Schlagwörter	Cognitive Tests; Intelligence Quotient; Mental Retardation; Infants; Screening Tests; Adults; Scores; Longitudinal Studies; Dietetics; Metabolism; Prevention; Disabilities; Genetics; Diseases; California + Suchen Sie Ihr Suchwort? Kognitiver Fähigkeitstest; Intelligenzquotient; Geistige Behinderung; Infant; Toddler; Toddlers; Kleinkind; Screening-Verfahren; Longitudinal study; Longitudinal method; Longitudinal methods; Längsschnittuntersuchung; Ernährungslehre; Stoffwechsel; Prävention; Vorbeugung; Handicap; Behinderung; Humangenetik; Disease; Krankheit; Kalifornien
Abstract	Individuals with late-treated phenylketonuria (PKU) not detected by newborn screening but who followed dietary treatment for at least 12 months before 7 years of age have intelligence quotient (IQ) scores that range from severe impairment to the low-normal range. Among adults with late-treated PKU in California, 85% of those who were born from 1961 to 1978 had IQ scores of 70 or above. Longitudinal studies with repeated cognitive assessments often show average changes in cognitive test scores as high as 20-45 points. Although the severe cognitive impairment associated with untreated PKU can in many cases be partially reversed with dietary treatment, prompt initiation of treatment following newborn metabolic screening is essential for optimal development and the prevention of disability. (Contains 2 tables.) (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10