Kinematics of Disease Progression in Bulbar ALS

Autor/inn/en	Yunusova, Yana; Green, Jordan R.; Lindstrom, Mary J.; Ball, Laura J.; Pattee, Gary L.; Zinman, Lorne
Titel	Kinematics of Disease Progression in Bulbar ALS
Quelle	In: Journal of Communication Disorders, 43 (2010) 1, S.6-20 (15 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0021-9924
DOI	10.1016/j.jcomdis.2009.07.003
Schlagwörter	Speech Communication; Diseases; Longitudinal Studies; Speech Impairments; Measures (Individuals); Articulation (Speech); Statistical Analysis; Physiology; Symptoms (Individual Disorders) + Suchen Sie Ihr Suchwort? Disease; Krankheit; Longitudinal study; Longitudinal method; Longitudinal methods; Längsschnittuntersuchung; Speech impairment; Speech handicap; Speech handicaps; Language handicps; Language impairments; Sprachbehinderung; Messdaten; Statistische Analyse; Physiologie; Psychiatrische Symptomatik
Abstract	The goal of this study was to investigate the deterioration of lip and jaw movements during speech longitudinally in three individuals diagnosed with bulbar amyotrophic lateral sclerosis (ALS). The study was motivated by the need to understand the relationship between physiologic changes in speech movements and clinical measures of speech performance such as speaking rate and speech intelligibility. Movements of the lip and jaw were quantified with respect to their size speed, and duration. The data revealed several changes in lip and jaw movement that coincided with ALS progression. In two out of three speakers, the changes in measures of path distance and speed anticipated the drop in speech intelligibility by approximately 3 months. With disease progression, increases in movement duration coincided with declines in speech intelligibility. Overall, the movement measures appeared to be sensitive to disease progression in ALS. Learning outcomes: By the end of the manuscript, the reader should be able to: (1) describe the changes that occur in articulatory movements of the jaw and lower lip in ALS; (2) understand the relationship between physiologic measures of movement and speech intelligibility and speaking rate; (3) identify critical points in the disease progression and understand which quantitative measures reveal the state of the bulbar system at these time points. (Contains 4 tables and 6 figures.) (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10