Material-Specific Lateralization of Working Memory in the Medial Temporal Lobe

Autor/inn/en	Wagner, Dylan D.; Sziklas, Viviane; Garver, Krista E.; Jones-Gotman, Marilyn
Titel	Material-Specific Lateralization of Working Memory in the Medial Temporal Lobe
Quelle	In: Neuropsychologia, 47 (2009) 1, S.112-122 (11 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0028-3932
DOI	10.1016/j.neuropsychologia.2008.08.010
Schlagwörter	Patients; Short Term Memory; Brain; Spatial Ability; Control Groups; Task Analysis; Brain Hemisphere Functions; Comparative Analysis; Verbal Stimuli + Suchen Sie Ihr Suchwort? Patient; Kurzzeitgedächtnis; Gehirn; Räumliches Vorstellungsvermögen; Aufgabenanalyse
Abstract	Mnemonic deficits in patients with medial temporal lobe (MTL) damage arising from temporal lobe epilepsy (TLE) are traditionally constrained to long-term episodic memory, sparing short-term and working memory (WM). This view of WM as being independent of MTL structures has recently been challenged by a small number of patient and neuroimaging studies, which have focused primarily on visual and visuospatial WM. In the present study we investigated material-specific lateralization of WM in 96 patients with unilateral damage to MTL stemming from TLE (56 left) and 30 control subjects using a pair of matched verbal and visuospatial supraspan tasks. Patients with unilateral TLE were impaired on both verbal and visuospatial WM tasks irrespective of the affected hemisphere. Patients with unilateral right TLE showed an additional deficit for visuospatial WM capacity when contrasted with patients with left TLE, whereas patients with unilateral left TLE showed increased intrusion errors on the verbal task when compared to patients with right TLE. These findings suggest a material-specific lateralization of WM in the MTL. (Contains 3 figures and 3 tables.) (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10