Switching between Abstract Rules Reflects Disease Severity but Not Dopaminergic Status in Parkinson's Disease

Autor/inn/en	Kehagia, Angie A.; Cools, Roshan; Barker, Roger A.; Robbins, Trevor W.
Titel	Switching between Abstract Rules Reflects Disease Severity but Not Dopaminergic Status in Parkinson's Disease
Quelle	In: Neuropsychologia, 47 (2009) 4, S.1117-1127 (11 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0028-3932
DOI	10.1016/j.neuropsychologia.2009.01.002
Schlagwörter	Stimuli; Diseases; Pathology; Rating Scales; Patients; Severity (of Disability); Neurological Impairments; Cognitive Mapping; Task Analysis; Drug Therapy; Brain Hemisphere Functions; Scores; Prediction; Cognitive Processes + Suchen Sie Ihr Suchwort? Anreizsystem; Disease; Krankheit; Pathologie; Rating-Skala; Patient; Schweregrad; Neurodegenerative Erkrankung; Aufgabenanalyse; Vorhersage; Cognitive process; Kognitiver Prozess
Abstract	This study sought to disambiguate the impact of Parkinson's disease (PD) on cognitive control as indexed by task set switching, by addressing discrepancies in the literature pertaining to disease severity and paradigm heterogeneity. A task set is governed by a rule that determines how relevant stimuli (stimulus set) map onto specific responses (response set). Task set switching may entail reconfiguration in either or both of these components. Although previous studies have shown that PD patients are impaired at switching between stimuli, in the present study not all patients were impaired at switching entire task sets, that is, both stimulus and response sets: compared with controls, patients with unilateral signs (Hoehn & Yahr Stage I) demonstrated intact switching, even following withdrawal from dopaminergic medication, while bilaterally affected Stage II patients were impaired. The parametric measure of Unified Parkinson's Disease Rating Scale (UPDRS) score predicted increasing switch costs within the patient group. These findings suggest that switching entire task sets may be a function of extrastriatal, possibly non-dopaminergic pathology which increases as the disease progresses. (Contains 3 figures and 6 tables.) (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10