Brief Report: Parental Age and the Sex Ratio in Autism

Autor/inn/en	Anello, Alene; Reichenberg, Abraham; Luo, Xiaodong; Schmeidler, James; Hollander, Eric; Smith, Christopher J.; Puleo, Connor M.; Kryzak, Lauren A.; Silverman, Jeremy M.
Titel	Brief Report: Parental Age and the Sex Ratio in Autism
Quelle	In: Journal of Autism and Developmental Disorders, 39 (2009) 10, S.1487-1492 (6 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0162-3257
DOI	10.1007/s10803-009-0755-y
Schlagwörter	Age Differences; Parent Influence; Gender Differences; Pervasive Developmental Disorders; Autism; Correlation; Genetics; Males; Females + Suchen Sie Ihr Suchwort? Age; Difference; Age difference; Altersunterschied; Geschlechterkonflikt; Autismus; Korrelation; Humangenetik; Male; Männliches Geschlecht; Weibliches Geschlecht
Abstract	The male-to-female (M:F) ratio for autism spectrum disorders (ASD), typically about 4:1, appears to decrease with increasing paternal age, but this relationship has not been systematically tested. With 393 ASD cases from families with two or more ASD cases, we categorized paternal age into five age groups (less than 30, 30-34, 35-39, 40-44, 45+) and found that the M:F ratio was significantly decreased with increasing paternal age groups and remained so after also adjusting for maternal age. No significant relationship between maternal age group and the M:F ratio was observed. This study suggests that the M:F ratio is reduced with increasing paternal age consistent with de novo genetic or genomic anomalies arising more frequently as men age and then conceive children. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10