The Ketogenic Diet Improves Recently Worsened Focal Epilepsy

Autor/inn/en	Villeneuve, Nathalie; Pinton, Florence; Bahi-Buisson, Nadia; Dulac, Olivier; Chiron, Catherine; Nabbout, Rima
Titel	The Ketogenic Diet Improves Recently Worsened Focal Epilepsy
Quelle	In: Developmental Medicine & Child Neurology, 51 (2009) 4, S.276-281 (6 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0012-1622
DOI	10.1111/j.1469-8749.2008.03216.x
Schlagwörter	Symptoms (Individual Disorders); Comparative Analysis; Epilepsy; Seizures; Dietetics; Patients; Children; Adolescents; Infants; Outcomes of Treatment; Intervention; Drug Therapy + Suchen Sie Ihr Suchwort? Psychiatrische Symptomatik; Epilepsie; Anfallsleiden; Ernährungslehre; Patient; Child; Kind; Kinder; Adolescent; Adolescence; Adoleszenz; Jugend; Jugendalter; Jugendlicher; Infant; Toddler; Toddlers; Kleinkind
Abstract	Aim: We observed a dramatic response to the ketogenic diet in several patients with highly refractory epilepsy whose seizure frequency had recently worsened. This study aimed to identify whether this characteristic was a useful indication for the ketogenic diet. Method: From the 70 patients who received the ketogenic diet during a 3-year period at our institution, we retrospectively selected patients with focal epilepsy. There were 22 children, 13 females and nine males, aged from 5 months to 18 years 6 months (mean 6y 9mo, SD 5y 11mo). Fifteen had symptomatic and seven had cryptogenic focal epilepsy. Seizure frequency 1 week before initiating the ketogenic diet was compared with that at 1 month and at the last visit on the diet. Results: Eleven patients were responders (defined as reduction of seizures by more than 50%) at 1 month. Responders were higher (p=0.046) in the group with a recent worsening of seizures than in those with stable seizure frequency. Seven patients were still seizure-free at 6 months on the diet. Tolerability was excellent in 10 patients. Five patients stopped the diet because of early side effects. Interpretation: The ketogenic diet may be a valuable therapeutic option for children with pharmacoresistant focal epilepsy, particularly those with a recent deterioration of seizure control and neurological status. Because of its rapid effect, the ketogenic diet may be a useful support to intravenous emergency drugs in such a situation. (As Provided).
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Update	2017/4/10