Lateralized Spatial and Object Memory Encoding in Entorhinal and Perirhinal Cortices

Autor/inn/en	Bellgowan, Patrick S. F.; Buffalo, Elizabeth A.; Bodurka, Jerzy; Martin, Alex
Titel	Lateralized Spatial and Object Memory Encoding in Entorhinal and Perirhinal Cortices
Quelle	In: Learning & Memory, 16 (2009) 7, S.433-438 (6 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.1357309
Schlagwörter	Brain Hemisphere Functions; Recognition (Psychology); Spatial Ability; Diagnostic Tests; Magnets; Visual Stimuli; Visual Perception; Memory; Animals; Cognitive Processes + Suchen Sie Ihr Suchwort? Recognition; Wiedererkennen; Räumliches Vorstellungsvermögen; Diagnostic test; Diagnostischer Test; Stabmagnet; Visuelle Wahrnehmung; Gedächtnis; Animal; Tier; Tiere; Cognitive process; Kognitiver Prozess
Abstract	The perirhinal and entorhinal cortices are critical components of the medial temporal lobe (MTL) declarative memory system. Study of their specific functions using blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI), however, has suffered from severe magnetic susceptibility signal dropout resulting in poor temporal signal-to-noise (tSNR) and thus weak BOLD signal detectability. We have demonstrated that higher spatial resolution in the z-plane leads to improved BOLD fMRI signal quality in the anterior medial temporal lobes when using a 16-element surface coil array at 3 T (Tesla). Using this technique, the present study investigated the roles of the anterior medial temporal lobe, particularly the entorhinal and perirhinal cortices, in both object and spatial memory. Participants viewed a series of fractal images and were instructed to encode either the object's identity or location. Object and spatial recognition memory were tested after 18-sec delays. Both the perirhinal and entorhinal cortices were active during the object and spatial encoding tasks. In both regions, object encoding was biased to the left hemisphere, whereas spatial encoding was biased to the right. A similar hemispheric bias was evident for recognition memory. Recent animal studies suggest functional dissociations among regions of the entorhinal cortex for spatial vs. object processing. Our findings suggest that this process-specific distinction may be expressed in the human brain as a hemispheric division of labor. (Contains 1 table and 5 figures.) (As Provided).
Anmerkungen	Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://www.learnmem.org/
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10