Memory Deficits Are Associated with Impaired Ability to Modulate Neuronal Excitability in Middle-Aged Mice

Autor/inn/en	Kaczorowski, Catherine C.; Disterhoft, John F.
Titel	Memory Deficits Are Associated with Impaired Ability to Modulate Neuronal Excitability in Middle-Aged Mice
Quelle	In: Learning & Memory, 16 (2009) 6, S.362-366 (5 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.1365609
Schlagwörter	Animals; Aging (Individuals); Memory; Fear; Neurological Organization; Brain; Brain Hemisphere Functions; Age Differences; Context Effect; Cognitive Ability; Learning Processes + Suchen Sie Ihr Suchwort? Animal; Tier; Tiere; Aging; Altern; Gedächtnis; Furcht; Gehirn; Age; Difference; Age difference; Altersunterschied; Denkfähigkeit; Learning process; Lernprozess
Abstract	Normal aging disrupts hippocampal neuroplasticity and learning and memory. Aging deficits were exposed in a subset (30%) of middle-aged mice that performed below criterion on a hippocampal-dependent contextual fear conditioning task. Basal neuronal excitability was comparable in middle-aged and young mice, but learning-related modulation of the post-burst afterhyperpolarization (AHP)--a general mechanism engaged during learning--was impaired in CA1 neurons from middle-aged weak learners. Thus, modulation of neuronal excitability is critical for retention of context fear in middle-aged mice. Disruption of AHP plasticity may contribute to contextual fear deficits in middle-aged mice--a model of age-associated cognitive decline (AACD). (As Provided).
Anmerkungen	Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://www.learnmem.org/
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10