Assessment of Aging Individuals with Down Syndrome in Clinical Trials: Results of Baseline Measures

Autor/inn/en	Sano, Mary; Aisen, Paul S.; Dalton, Arthur J.; Andrews, Howard F.; Tsai, Wei-Yann
Titel	Assessment of Aging Individuals with Down Syndrome in Clinical Trials: Results of Baseline Measures
Quelle	In: Journal of Policy and Practice in Intellectual Disabilities, 2 (2005) 2, S.126-138 (13 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1741-1122
DOI	10.1111/j.1741-1130.2005.00021.x
Schlagwörter	Mental Retardation; Alzheimers Disease; Dementia; Down Syndrome; Verbal Learning; Cognitive Tests; Rating Scales; Memory; Aging (Individuals); Measures (Individuals); Cognitive Processes; Behavior Problems; Neurological Impairments; Vocabulary; Recall (Psychology); Correlation; Visual Perception; Evaluation Methods + Suchen Sie Ihr Suchwort? Geistige Behinderung; Demenz; 'Downs Syndrome; Down''s Syndrome'; Down-Syndrom; Verbales Lernen; Kognitiver Fähigkeitstest; Rating-Skala; Gedächtnis; Aging; Altern; Messdaten; Cognitive process; Kognitiver Prozess; Neurodegenerative Erkrankung; Wortschatz; Abberufung; Korrelation; Visuelle Wahrnehmung
Abstract	A major challenge to developing therapeutic interventions for cognitive loss and dementia in aging individuals with Down syndrome (DS) is the selection of appropriate outcome measures. This report describes the adaptation of the Brief Praxis Test (a nonverbal cognitive test) as a primary outcome measure, as well as the selection of secondary outcome measures for a multicenter clinical trial of vitamin E in aging individuals with DS. Instruments were chosen to assess cognition, behavior, and clinical global function based on previous work in DS and in Alzheimer's disease. Measures of cognition included verbal and nonverbal memory, vocabulary, and orientation. An informant-based measure of behavior and function was adapted from several existing rating scales, and the Clinical Global Impression was adapted for use with this group. This report also describes initial experiences using these measures with the participants who were enrolled in the clinical trial. As in other populations of persons with dementia, verbal learning, memory, and delayed recall proved to be highly associated with the presence of dementia in our study participants. With the exception of visual memory and orientation measures (which proved too difficult to use with portions of this cohort), the tests employed proved useful in the assessment of individuals across a range of premorbid levels of intellectual disability. The authors conclude that the measures chosen for the assessment of behavior and functional ability and the use of the Clinical Global Impression appear to be appropriate for this population and comparable to instruments that have captured pharmacological benefits in other disease groups. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10