Literaturnachweis - Detailanzeige
Autor/inn/en | Garcia-Osta, Ana; Alberini, Cristina M. |
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Titel | Amyloid Beta Mediates Memory Formation |
Quelle | In: Learning & Memory, 16 (2009) 4, S.267-272 (6 Seiten)
PDF als Volltext |
Sprache | englisch |
Dokumenttyp | gedruckt; online; Zeitschriftenaufsatz |
ISSN | 1072-0502 |
DOI | 10.1101/lm.1310209 |
Schlagwörter | Alzheimers Disease; Memory; Animals; Experiments; Short Term Memory |
Abstract | The amyloid precursor protein (APP) undergoes sequential cleavages to generate various polypeptides, including the amyloid [beta] (1-42) peptide (A[beta][1-42]), which is believed to play a major role in amyloid plaque formation in Alzheimer's disease (AD). Here we provide evidence that, in contrast with its pathological role when accumulated, endogenous A[beta] in normal hippocampi mediates learning and memory formation. Furthermore, hippocampal injection of picomolar concentrations of exogenous A[beta](1-42) enhances memory consolidation. Correlative data suggest that A[beta] peptides may exert their function via nicotinic acetylcoline receptors. Hence, A[beta] peptides, including A[beta](1-42), play an important physiological role in hippocampal memory formation. (Contains 3 figures.) (As Provided). |
Anmerkungen | Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://www.learnmem.org/ |
Erfasst von | ERIC (Education Resources Information Center), Washington, DC |
Update | 2017/4/10 |