Extensions of a Basic Laboratory Experiment: [4+2] and [2+2] Cycloadditions

Autor/inn/en	Amarne, Hazem Y.; Bain, Alex D.; Neumann, Karen; Zelisko, Paul M.
Titel	Extensions of a Basic Laboratory Experiment: [4+2] and [2+2] Cycloadditions
Quelle	In: Journal of Chemical Education, 85 (2008) 1, S.104-106 (3 Seiten)Infoseite zur Zeitschrift PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0021-9584
Schlagwörter	Research Methodology; Chemistry; Laboratory Experiments; College Science; Undergraduate Students; Hands on Science; Science Instruction; Science Activities; Teaching Methods; Models; Scientific Concepts + Suchen Sie Ihr Suchwort? Research method; Forschungsmethode; Chemie; Laboratory work; Laborarbeit; Teaching of science; Science education; Natural sciences Lessons; Naturwissenschaftlicher Unterricht; Teaching method; Lehrmethode; Unterrichtsmethode; Analogiemodell
Abstract	We describe an extended third-year undergraduate chemistry laboratory exercise in which a number of techniques and concepts are applied to the same set of chemical reactions. The reactions are the photochemical and thermal cycloadditions of [beta]-nitrostyrene and 2,3-dimethylbutadiene. This can be viewed as a single long lab or a series of connected exercises exploring a number of themes. This serves as an example of the goals and pedagogy used in a course designed to prepare students for a fourth-year undergraduate thesis. The exercises include synthesis, NMR spectroscopy, and computer-based molecular modeling. The same reagents are used, but the photochemical reaction gives the [2+2] product and the thermal reaction produces the [4+2] product. These reactions are used as a basis for discussions of a number of topics: the Woodward-Hoffmann rules, stereochemistry and regiochemistry, kinetic versus thermodynamic control of reactions, analysis of stereochemistry by 1D NMR, introduction of 2D NMR methods, molecular modeling, and use of computer programs for accurate visualization. This set of exercises is an example of an extension of the typical three-hour lab into more detailed investigations and an introduction to research methods. (As Provided).
Anmerkungen	Division of Chemical Education of the American Chemical Society. Subscription Department, P.O. Box 1267, Bellmawr, NJ 08099-1267. Tel: 800-691-9846; Tel: 856-931-5825; Fax: 856-931-4115; e-mail: jchemed@egpp.com; Web site: http://www.jce.divched.org
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10