Synthesis of the Commercial Antidepressant Moclobemide

Autor/in	More, Jesse D.
Titel	Synthesis of the Commercial Antidepressant Moclobemide
Quelle	In: Journal of Chemical Education, 85 (2008) 10, S.1424-1425 (2 Seiten)Infoseite zur Zeitschrift PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0021-9584
Schlagwörter	Organic Chemistry; Drug Therapy; Undergraduate Study; Science Laboratories; Science Instruction; College Science; Spectroscopy; Thermodynamics; Science Experiments + Suchen Sie Ihr Suchwort? Organische Chemie; Grundstudium; Teaching of science; Science education; Natural sciences Lessons; Naturwissenschaftlicher Unterricht; Spektroskopie; Thermodynamik
Abstract	An experiment for the undergraduate organic chemistry laboratory is described in which students synthesize the commercial antidepressant drug moclobemide, marketed under the trade name Manerix. This one-step synthesis starts from commercially available material and produces moclobemide in high yield. The product is initially isolated as its hydrochloride salt via precipitation. After recrystallization and treatment with base moclobemide is isolated in pure form. The purity and identity of the product are confirmed by melting point and NMR and IR spectroscopy. (Contains 2 figures and 2 schemes.) (As Provided).
Anmerkungen	Division of Chemical Education of the American Chemical Society. Subscription Department, P.O. Box 1267, Bellmawr, NJ 08099-1267. Tel: 800-691-9846; Tel: 856-931-5825; Fax: 856-931-4115; e-mail: jchemed@egpp.com; Web site: http://www.jce.divched.org
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10