Autism Profiles of Males With Fragile X Syndrome

Autor/inn/en	Harris, Susan W.; Hessl, David; Goodlin-Jones, Beth; Ferranti, Jessica; Bacalman, Susan; Barbato, Ingrid; Tassone, Flora; Hagerman, Paul J.; Herman, Kristin; Hagerman, Randi J.
Titel	Autism Profiles of Males With Fragile X Syndrome
Quelle	In: American Journal on Mental Retardation, 113 (2008) 6, S.427-438 (12 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0895-8017
DOI	10.1352/2008.113:427-438
Schlagwörter	Autism; Males; Genetics; Profiles; Clinical Diagnosis; Classification; Symptoms (Individual Disorders); Molecular Structure + Suchen Sie Ihr Suchwort? Autismus; Male; Männliches Geschlecht; Humangenetik; Charakterisierung; Profilanalyse; Classification system; Klassifikation; Klassifikationssystem; Psychiatrische Symptomatik
Abstract	Autism, which is common in individuals with fragile X syndrome, is often difficult to diagnose. We compared the diagnostic classifications of two measures for autism diagnosis, the ADOS and the ADI-R, in addition to the DSM-IV-TR in 63 males with this syndrome. Overall, 30% of the subjects met criteria for autistic disorder and 30% met criteria for PDD-NOS. The classifications on the ADOS and DSM-IV-TR were most similar, whereas the ADI-R classified subjects as autistic much more frequently. We further investigated the relationship of both FMRP and FMR1 mRNA to symptoms of autism in this cohort and found no significant relationship between the measures of autism and molecular features, including FMRP, FMR1 mRNA, and CGG repeat number. (As Provided).
Anmerkungen	American Association on Intellectual and Developmental Disabilities. P.O. Box 1897, Lawrence, KS 66044-1897. Tel: 785-843-1235; Fax: 785-843-1274; e-mail: AJMR@allenpress.com; Web site: http://aaidd.allenpress.com
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10