Primary Cortical Folding in the Human Newborn: An Early Marker of Later Functional Development

Autor/inn/en	Dubois, J.; Benders, M.; Borradori-Tolsa, C.; Cachia, A.; Lazeyras, F.; Leuchter, R. Ha-Vinh; Sizonenko, S. V.; Warfield, S. K.; Mangin, J. F.; Huppi, P. S.
Titel	Primary Cortical Folding in the Human Newborn: An Early Marker of Later Functional Development
Quelle	In: Brain, 131 (2008) 8, S.2028-2041 (14 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0006-8950
DOI	10.1093/brain/awn137
Schlagwörter	Twins; Neonates; Brain; Infants; Brain Hemisphere Functions; Child Development; Neurological Impairments; Developmental Disabilities; Diagnostic Tests; Premature Infants; Predictor Variables + Suchen Sie Ihr Suchwort? Twin; Zwilling; Neugeborenes Kind; Gehirn; Infant; Toddler; Toddlers; Kleinkind; Kindesentwicklung; Neurodegenerative Erkrankung; Entwicklungsstörung; Diagnostic test; Diagnostischer Test; Frühgeburt; Prädiktor
Abstract	In the human brain, the morphology of cortical gyri and sulci is complex and variable among individuals, and it may reflect pathological functioning with specific abnormalities observed in certain developmental and neuropsychiatric disorders. Since cortical folding occurs early during brain development, these structural abnormalities might be present long before the appearance of functional symptoms. So far, the precise mechanisms responsible for such alteration in the convolution pattern during intra-uterine or post-natal development are still poorly understood. Here we compared anatomical and functional brain development "in vivo" among 45 premature newborns who experienced different intra-uterine environments: 22 normal singletons, 12 twins and 11 newborns with intrauterine growth restriction (IUGR). Using magnetic resonance imaging (MRI) and dedicated post-processing tools, we investigated early disturbances in cortical formation at birth, over the developmental period critical for the emergence of convolutions (26-36 weeks of gestational age), and defined early "endophenotypes" of sulcal development. We demonstrated that twins have a delayed but harmonious maturation, with reduced surface and sulcation index compared to singletons, whereas the gyrification of IUGR newborns is discordant to the normal developmental trajectory, with a more pronounced reduction of surface in relation to the sulcation index compared to normal newborns. Furthermore, we showed that these structural measurements of the brain at birth are predictors of infants' outcome at term equivalent age, for MRI-based cerebral volumes and neurobehavioural development evaluated with the assessment of preterm infant's behaviour (APIB). (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10