Anterograde and Retrograde Amnesia of Place Discrimination in Retrosplenial Cortex and Hippocampal Lesioned Rats

Autor/inn/en	Haijima, Asahi; Ichitani, Yukio
Titel	Anterograde and Retrograde Amnesia of Place Discrimination in Retrosplenial Cortex and Hippocampal Lesioned Rats
Quelle	In: Learning & Memory, 15 (2008) 7, S.477-482 (6 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.862308
Schlagwörter	Control Groups; Intervals; Surgery; Memory; Animals; Neurological Impairments; Brain Hemisphere Functions; Task Analysis; Retention (Psychology); Spatial Ability + Suchen Sie Ihr Suchwort? Chirurgie; Gedächtnis; Animal; Tier; Tiere; Neurodegenerative Erkrankung; Aufgabenanalyse; Merkfähigkeit; Räumliches Vorstellungsvermögen
Abstract	Retrograde and anterograde amnesic effects of excitotoxic lesions of the rat retrosplenial cortex (RS) and hippocampus (HPC) were investigated. To test retrograde amnesia, rats were trained with two-arm place discrimination in a radial maze 4 wk and 1 d before surgery with a different arm pair, respectively. In the retention test 1 wk after surgery, both lesion groups showed temporally ungraded retrograde amnesia. To test anterograde amnesia, animals were trained after surgery to discriminate three arm pairs successively within a day, and then after interposition of 1- to 4-wk intervals, one of these pairs, respectively, was tested for retention. RS-lesioned rats could acquire these pairs of place discriminations rapidly but showed a retention interval-dependent impairment in the retention test. Conversely, HPC-lesioned rats took more sessions to acquire these pairs than did the control group, and their retention was approximately 70% of correct performance regardless of retention interval. Results suggest that RS and HPC have different roles in spatial memory and that RS is important for remote memory process. (As Provided).
Anmerkungen	Cold Spring Harbor Laboratory Press. 500 Sunnyside Blvd, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://www.learnmem.org/
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10