Are There Enhanced MBP Autoantibodies in Autism?

Autor/inn/en	Libbey, Jane E.; Coon, Hilary H.; Kirkman, Nikki J.; Sweeten, Thayne L.; Miller, Judith N.; Stevenson, Edward K.; Lainhart, Janet E.; McMahon, William M.; Fujinami, Robert S.
Titel	Are There Enhanced MBP Autoantibodies in Autism?
Quelle	In: Journal of Autism and Developmental Disorders, 38 (2008) 2, S.324-332 (9 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0162-3257
DOI	10.1007/s10803-007-0400-6
Schlagwörter	Play; Autism; Anatomy; Pervasive Developmental Disorders; Biochemistry; Neuropsychology; Control Groups; Individual Differences; Brain + Suchen Sie Ihr Suchwort? Spiel; Autismus; Anatomie; Biochemie; Neuropsychologie; Individueller Unterschied; Gehirn
Abstract	Autoantibodies to central nervous system antigens, such as myelin basic protein (MBP), may play a role in autism. We measured autoantibody titers to MBP in children with autism, both classic onset and regressive onset forms, controls (healthy age- and gender-matched) and individuals with Tourette syndrome via enzyme-linked immunosorbent assays. We found a significant difference in autoantibody titers to MBP, not accounted for by age or medication, between Tourette and classic autism (both significantly lower) when compared to regressive autism, but not when compared to controls. Autoantibody responses against MBP are unlikely to play a pathogenic role in autism. (Author).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10