Adult Visual Experience Promotes Recovery of Primary Visual Cortex from Long-Term Monocular Deprivation

Autor/inn/en	Fischer, Quentin S.; Aleem, Salman; Zhou, Hongyi; Pham, Tony A.
Titel	Adult Visual Experience Promotes Recovery of Primary Visual Cortex from Long-Term Monocular Deprivation
Quelle	In: Learning & Memory, 14 (2007) 9, S.573-580 (8 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.676707
Schlagwörter	Environmental Influences; Human Body; Vision; Visual Impairments; Communication Research; Brain; Adults; Animals; Visual Perception; Visual Stimuli + Suchen Sie Ihr Suchwort? Environmental influence; Umwelteinfluss; Menschlicher Körper; Visual handicap; Sehbehinderung; Kommunikationsforschung; Gehirn; Animal; Tier; Tiere; Visuelle Wahrnehmung
Abstract	Prolonged visual deprivation from early childhood to maturity is believed to cause permanent visual impairment. However, there have been case reports of substantial improvement of binocular vision in human adults following lifelong visual impairment or deprivation. These observations, together with recent findings of adult ocular dominance plasticity in rodents, led us to re-examine whether adult primary visual cortex (V1) is capable of any recovery following long-term monocular deprivation starting in development. Using mice as a model, we find that monocular deprivation from early development to mature ages (well past the critical period) severely impaired binocular vision by reducing the amplitude of responses elicited by stimulation of the deprived eye. Surprisingly, we find little effect on nondeprived eye responses. Restoration of binocular vision in mature adults yields modest but significant improvement of visual responses in V1. Remarkably, we find that when binocular vision is followed by occlusion of the nondeprived eye, visual responses in V1 recover almost fully, as measured by visual evoked potential amplitude, spatial frequency threshold, and single-unit activity. We conclude that adult V1 can recover from long-term deprivation when provided with an optimal regimen of visual experience. (Contains 6 figures.) (Author).
Anmerkungen	Cold Spring Harbor Laboratory Press. 500 Sunnyside Blvd, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://www.learnmem.org/
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10