LTP Induction Modifies Functional Relationship among Hippocampal Neurons

Autor/inn/en	Yun, Sung H.; Lee, Deok S.; Lee, Hyunjung; Baeg, Eun H.; Kim, Yun B.; Jung, Min W.
Titel	LTP Induction Modifies Functional Relationship among Hippocampal Neurons
Quelle	In: Learning & Memory, 14 (2007) 3, S.190-194 (5 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
Schlagwörter	Long Term Memory; Mnemonics; Perceptual Motor Coordination; Stimulation; Conditioning; Neuropsychology; Molecular Biology; Brain Hemisphere Functions; Animal Behavior; Science Experiments; Scientific Methodology + Suchen Sie Ihr Suchwort? Langzeitgedächtnis; Mnemotechnik; Körperkoordination; Neuropsychologie; Molekularbiologie; Tierverhalten
Abstract	To obtain evidence linking long-term potentiation (LTP) and memory, we examined whether LTP induction modifies functional relationship among neurons in the rat hippocampus. In contrast to neurons in low-frequency stimulated or AP5-treated slices, LTP induction altered "functional connectivity," as defined by the degree of synchronous firing, among simultaneously recorded neurons in the CA3 region. Interestingly, functional connectivity changed bidirectionally so that the total sum of functional connectivity remained constant. These results demonstrate LTP-induced changes in neuronal functional connectivity and suggest the existence of a normalization mechanism for the total sum of functional connectivity. (Author).
Anmerkungen	Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://www.learnmem.org/
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10