A Role for Prefrontal Calcium-Sensitive Protein Phosphatase and Kinase Activities in Working Memory

Autor/inn/en	Runyan, Jason D.; Moore, Anthony N.; Dash, Pramod K.
Titel	A Role for Prefrontal Calcium-Sensitive Protein Phosphatase and Kinase Activities in Working Memory
Quelle	In: Learning & Memory, 12 (2005) 2, S.103-110 (8 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
Schlagwörter	Memory; Role Perception; Molecular Biology; Molecular Structure; Neurology; Brain Hemisphere Functions; Neuropsychology; Biological Influences; Scientific Methodology; Scientific Research + Suchen Sie Ihr Suchwort? Gedächtnis; Role conception; Rollenverständnis; Molekularbiologie; Neurologie; Neuropsychologie; Biologischer Faktor
Abstract	The prefrontal cortex is involved in the integration and interpretation of information for directing thoughts and planning action. Working memory is defined as the active maintenance of information in mind and is thought to lie at the core of many prefrontal functions. Although dopamine and other neurotransmitters have been implicated, the intracellular events activated by their receptors that influence working memory are poorly understood. We demonstrate that working memory involves transient changes in prefrontal G[subscript q/11]-signaling and in calcium-dependent intracellular protein phosphatase and kinase activity. Interestingly, inhibition of the calcium activated phosphatase calcineurin impaired, while calcium/calmodulin dependent kinase II (CaMKII) and calcium-dependent protein kinase C (PKC) enhanced, working memory. Our findings suggest that the active maintenance of information required for working memory involves transient changes in the balance of these enzymes' activities. (Contains 4 figures.) (Author).
Anmerkungen	Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://www.learnmem.org/
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10