Opposing Actions of Chronic[Deta][superscript 9] Tetrahydrocannabinol and Cannabinoid Antagonists on Hippocampal Long-Term Potentiation

Autor/inn/en	Hoffman, Alexander F.; Oz, Murat; Yang, Ruiqin; Lichtman, Aron H.; Lupica, Carl R.
Titel	Opposing Actions of Chronic[Deta][superscript 9] Tetrahydrocannabinol and Cannabinoid Antagonists on Hippocampal Long-Term Potentiation
Quelle	In: Learning & Memory, 14 (2007) 1-2, S.63-74 (12 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
Schlagwörter	Marijuana; Neurological Impairments; Drug Abuse; Spectroscopy; Cytology; Anatomy; Brain Hemisphere Functions; Molecular Biology; Science Experiments; Scientific Methodology; Animals; Long Term Memory; Mnemonics + Suchen Sie Ihr Suchwort? Neurodegenerative Erkrankung; Spektroskopie; Zytologie; Anatomie; Molekularbiologie; Animal; Tier; Tiere; Langzeitgedächtnis; Mnemotechnik
Abstract	Memory deficits produced by marijuana arise partly via interaction of the psychoactive component, [Deta][superscript 9]-tetrahydrocannabinol ([Deta][superscript 9]-THC), with cannabinoid receptors in the hippocampus. Although cannabinoids acutely reduce glutamate release and block hippocampal long-term potentiation (LTP), a potential substrate for learning and memory, the consequences of prolonged exposure to [Deta][superscript 9]-THC for hippocampal function are poorly understood. Rats were injected with [Deta][superscript 9]-THC (10 mg/kg, i.p., q.d.) for 1, 3, or 7 d, and electrophysiological recordings were performed in hippocampal slices 1d after the final injection. At this time, [Deta][superscript 9]-THC was undetectable in hippocampus using liquid chromatography-mass spectrometry (LC-MS). Hippocampal LTP generated using high-frequency (HFS) or theta burst stimulation was not observed in brain slices from the 7-d [Deta][superscript 9]-THC-treated animals. [Deta][superscript 9]-THC also blocked HFS-LTP after 3 d, but not 1 d of treatment. The complete blockade of LTP persisted for 3 d after the last [Deta][superscript 9]-THC injection, and full reversal of the LTP deficit was not observed up to 14 d following [Deta][superscript 9]-THC withdrawal. The cannabinoid antagonist AM251 (2 mg/kg), administered before each [Deta][superscript 9]-THC injection prevented the blockade of LTP, and 7-d treatment with AM251 alone significantly increased the level of LTP. Chronic [Deta][superscript 9]-THC also produced tolerance to the inhibition of synaptic GABA, but not glutamate release by the agonist WIN55,212-2. These data define consequences of repeated [Deta][superscript 9]-THC exposure for synaptic plasticity in the hippocampus that may help explain memory impairments in humans following chronic marijuana use. (Author).
Anmerkungen	Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://www.learnmem.org/
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10