Activation of the Transcription Factor NF-[Kappa]B by Retrieval Is Required for Long-Term Memory Reconsolidation

Autor/inn/en	Maldonado, Hector; Romano, Arturo; Merlo, Emiliano; Freudenthal, Ramiro
Titel	Activation of the Transcription Factor NF-[Kappa]B by Retrieval Is Required for Long-Term Memory Reconsolidation
Quelle	In: Learning & Memory, 12 (2005) 1, S.23-29 (7 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
Schlagwörter	Molecular Biology; Recall (Psychology); Long Term Memory; Animals; Sensory Training; Difficulty Level; Inhibition; Protocol Analysis; Scientific Methodology; Science Experiments; Role Perception; Brain Hemisphere Functions + Suchen Sie Ihr Suchwort? Molekularbiologie; Abberufung; Langzeitgedächtnis; Animal; Tier; Tiere; Sensorische Erziehung; Schwierigkeitsgrad; Hemmung; Role conception; Rollenverständnis
Abstract	Several studies support that stored memories undergo a new period of consolidation after retrieval. It is not known whether this process, termed reconsolidation, requires the same transcriptional mechanisms involved in consolidation. Increasing evidence supports the participation of the transcription factor NF-[Kappa]B in memory. This was initially demonstrated in the crab "Chasmagnathus" model of associative contextual memory, in which re-exposure to the training context induces a well characterized reconsolidation process. Here we studied the role of NF-[Kappa]B in reconsolidation. NF-[Kappa]B was specifically activated in trained animals re-exposed to the training context but not to a different context. NF-[Kappa]B was not activated when animals were re-exposed to the context after a weak training protocol insufficient to induce long-term memory. A specific inhibitor of the NF-[Kappa]B pathway, sulfasalazine, impaired reconsolidation when administered 20 min before re-exposure to the training context but was not effective when a different context was used. These findings indicate for the first time that NF-[Kappa]B is activated specifically by retrieval and that this activation is required for memory reconsolidation, supporting the view that this molecular mechanism is required in both consolidation and reconsolidation. (Contains 5 figures.) (Author).
Anmerkungen	Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://www.learnmem.org/
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10