Adult but Not Aged C57BL/6 Male Mice Are Capable of Using Geometry for Orientation

Autor/inn/en	Schachner, Melitta; Morellini, Fabio; Fellini, Laetitia
Titel	Adult but Not Aged C57BL/6 Male Mice Are Capable of Using Geometry for Orientation
Quelle	In: Learning & Memory, 13 (2006) 4, S.473-481 (9 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.259206
Schlagwörter	Animals; Spatial Ability; Geometric Concepts; Age Differences; Aging (Individuals); Geometry + Suchen Sie Ihr Suchwort? Animal; Tier; Tiere; Räumliches Vorstellungsvermögen; Elementare Geometrie; Age; Difference; Age difference; Altersunterschied; Aging; Altern; Geometrie
Abstract	Geometry, e.g., the shape of the environment, can be used by numerous animal species to orientate, but data concerning the mouse are lacking. We addressed the question of whether mice are capable of using geometry for navigating. To test whether aging could affect searching strategies, we compared adult (3- to 5-mo old) and aged (20- to 21-mo old) C57BL/6 male mice. We established a water maze task in which spatial information is provided by one landmark proximal to the target (featural information) and by the rectangular shape of the maze (geometric information). By means of probe trials in which we manipulated the presence of these two kinds of information, we show that adult mice can use both geometry and landmark to orientate. By contrast, aged mice do not use geometry and rely exclusively on the landmark to locate the platform. This study provides the first evidence that mice are capable of using geometric information for orientation and that this ability declines in aged animals. (Author).
Anmerkungen	Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://www.learnmem.org/
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10