NMDA and Muscarinic Receptors of the Nucleus Accumbens Have Differential Effects on Taste Memory Formation

Autor/inn/en	Bermudez-Rattoni, Federico; Ramirez-Lugo, Leticia; Zavala-Vega, Sergio
Titel	NMDA and Muscarinic Receptors of the Nucleus Accumbens Have Differential Effects on Taste Memory Formation
Quelle	In: Learning & Memory, 13 (2006) 1, S.45-51 (7 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.103206
Schlagwörter	Memory; Associative Learning; Scientific Research; Ethology; Conditioning; Defense Mechanisms; Behavior Modification; Scientific Methodology + Suchen Sie Ihr Suchwort? Gedächtnis; Ethologie; Abwehrverhalten; Behaviour modification; Verhaltensänderung
Abstract	Animals recognize a taste cue as aversive when it has been associated with post-ingestive malaise; this associative learning is known as conditioned taste aversion (CTA). When an animal consumes a new taste and no negative consequences follow, it becomes recognized as a safe signal, leading to an increase in its consumption in subsequent presentations (attenuation of neophobia, AN). It has been shown that the nucleus accumbens (NAcc) has an important role in taste learning. To elucidate the involvement of N-methyl-D-aspartate (NMDA) and muscarinic receptors in the NAcc during safe and aversive taste memory formation, we administrated bilateral infusions of DL-2-amino-5-phosphonopentanoic acid (APV) or scopolamine in the NAcc shell or core respectively. Our results showed that pre-training injections of APV in the NAcc core and shell disrupted aversive but not safe taste memory formation, whereas pre-training injections of scopolamine in the NAcc shell, but not core, disrupted both CTA and AN. These results suggest that muscarinic receptors seem to be necessary for processing taste stimuli for either safe or aversive taste memory, whereas NMDA receptors are only involved in the aversive taste memory trace formation. (Contains 4 figures.) (Author).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10