Childhood-Onset Bipolar Disorder: Evidence for Increased Familial Loading of Psychiatric Illness

Autor/inn/en	Rende, Richard; Birmaher, Boris; Axelson, David; Strober, Michael; Gill, Mary Kay; Valeri, Sylvia; Chiappetta, Laurel; Ryan, Neal; Leonard, Henrietta; Hunt, Jeffrey; Iyengar, Satish; Keller, Martin
Titel	Childhood-Onset Bipolar Disorder: Evidence for Increased Familial Loading of Psychiatric Illness
Quelle	In: Journal of the American Academy of Child and Adolescent Psychiatry, 46 (2007) 2, S.197-204 (8 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0890-8567
Schlagwörter	Psychopathology; Adolescents; Suicide; Hyperactivity; Depression (Psychology); Interviews; Genetics; Screening Tests; Anxiety; Attention Deficit Disorders; Substance Abuse; Children; Risk; Mental Disorders + Suchen Sie Ihr Suchwort? Psychopathologie; Adolescent; Adolescence; Adoleszenz; Jugend; Jugendalter; Jugendlicher; Selbstmord; Hyperaktivität; Interviewing; Interviewtechnik; Humangenetik; Screening-Verfahren; Angst; Attention deficit hyperactivity disorder; ADHS; Aufmerksamkeits-Defizit-Hyperaktivitäts-Störung; Aufmerksamkeitsstörung; Drug use; Drug consomption; Drogenkonsum; Child; Kind; Kinder; Risiko; Mental illness; Geisteskrankheit
Abstract	Objective: To determine whether childhood-onset bipolar disorder (BP) is associated with an increased psychiatric family history compared with adolescent-onset BP. Method: Semistructured psychiatric interviews were conducted for 438 youth with BP spectrum disorders. To evaluate the effects of age at onset and psychiatric family history, the sample was divided into childhood-onset BP (age and BP onset less than 12 years; n = 192), adolescents with early-onset BP (age greater than or equal to 12 years and BP onset less than 12 years; n = 136), and adolescents with late-onset BP (age and BP onset greater than or equal to 12 years; n = 110). Lifetime family history of psychiatric illness was ascertained for first- and second-degree relatives through both direct interview of caretakers and the Family History Screen. Results: After significant demographic and clinical factors were controlled for, children and adolescents with childhood-onset BP showed higher percentages of positive first-degree family history for depression, anxiety, attention deficit/hyperactivity, conduct, and substance dependence disorders and suicidal behaviors compared with adolescents with late onset. Subjects with childhood-onset BP also showed elevated familial loading for depression and attention-deficit/hyperactive disorder in second-degree relatives. Conclusions: These data support a model that postulates a higher density of familial risk for a broad range of psychopathology in childhood-onset BP. (Contains 4 tables.) (Author).
Anmerkungen	Lippincott Williams & Wilkins. P.O. Box 1600, Hagerstown, MD 21741. Tel: 800-638-3030; Tel: 301-223-2300; Fax: 301-223-2400; Web site: http://www.lww.com/product/?0890-8567
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10