A Controlled Family Study of Attention-Deficit/Hyperactivity Disorder and Tourette's Disorder

Autor/inn/en	Stewart, S. Evelyn; Illmann, Cornelia; Geller, Daniel A.; Leckman, James F.; King, Robert; Pauls, David L.
Titel	A Controlled Family Study of Attention-Deficit/Hyperactivity Disorder and Tourette's Disorder
Quelle	In: Journal of the American Academy of Child and Adolescent Psychiatry, 45 (2006) 11, S.1354-1362 (9 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0890-8567
Schlagwörter	Etiology; Hyperactivity; Genetics; Control Groups; Attention Deficit Disorders; Neurological Impairments; Family (Sociological Unit); Age; Clinical Diagnosis; Neurology; Pathology; Physiology + Suchen Sie Ihr Suchwort? Ätiologie; Hyperaktivität; Humangenetik; Attention deficit hyperactivity disorder; ADHS; Aufmerksamkeits-Defizit-Hyperaktivitäts-Störung; Aufmerksamkeitsstörung; Neurodegenerative Erkrankung; Familie; Alter; Lebensalter; Neurologie; Pathologie; Physiologie
Abstract	Objective: Although attention-deficit/hyperactivity disorder (ADHD) is frequently comorbid with Tourette's disorder (TD), it is unclear whether they have a common genetic etiology. Familial relationships between DSM-IVADHD and TD are studied in TD + ADHD, TD-only (TD-ADHD), ADHD-only (ADHD-TD), and control groups. Method: Case-control, direct-interview family study of 692 relatives of 75 TD + ADHD, 74 TD-only, 41 ADHD-only, and 49 control probands collected between 1999 and 2004. Age-corrected prevalence rates, odds ratios, and predictors of TD, ADHD, and OCD among relatives are estimated from blinded best-estimate diagnoses using survival Kaplan-Meier and generalized estimating equation regression analyses. Results: In relatives of the TD-only group, although ADHD exceeded control rates (p = 0.03), ADHD-TD (p = 0.51) rates were not increased. In the ADHD-only group, TD was increased (p = 0.004) but TD-ADHD rates were not increased (p = 0.18). Comorbid ADHD + TD diagnoses in relatives were elevated in all case groups (p less than or equal to 0.03). TD in relatives predicted comorbid ADHD (p less than 0.001), and ADHD in relatives predicted comorbid TD (p less than 0.001). OCD in relatives predicted both ADHD (p = 0.002) and TD (p less than 0.001) in relatives. Conclusions: TD and ADHD are not alternate phenotypes of a single underlying genetic cause. There is an increased risk of comorbid ADHD and TD in affected families, possibly reflecting some overlapping neurobiology or pathophysiology. (Contains 5 tables.) (Author).
Anmerkungen	Lippincott Williams & Wilkins. P.O. Box 1600, Hagerstown, MD 21741. Tel: 800-638-3030; Tel: 301-223-2300; Fax: 301-223-2400; Web site: http://www.lww.com/product/?0890-8567
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10